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Title: Transdermal Delivery of Anti-Obesity Compounds to Subcutaneous Adipose Tissue with Polymeric Microneedle Patches
Authors: Than, Aung
Liang, Ke
Xu, Shaohai
Sun, Lei
Duan, Hongwei
Xi, Fengna
Xu, Chenjie
Chen, Peng
Keywords: Microneedle
Transdermal delivery
Issue Date: 2017
Source: Than, A., Liang, K., Xu, S., Sun, L., Duan, H., Xi, F., Xu, C. & Chen, P. (2017). Transdermal Delivery of Anti-Obesity Compounds to Subcutaneous Adipose Tissue with Polymeric Microneedle Patches. Small Methods.
Series/Report no.: Small Methods
Abstract: Excess white adipose tissue (WAT), or obesity, is the leading cause of many diseases. Combating obesity is, however, challenging due to the fact that laboratory-proven anti-obesity compounds lose effectiveness or/and cause severe side-effects while being delivered via conventional routes. Here, a new strategy is reported using disposable transdermal patches equipped with detachable polymeric microneedle (MN) arrays for painless and bloodless drug delivery to subcutaneous WAT. In contrast to the current methods to reduce energy intake, MN-patches are used to deliver anti-obesity compounds to increase energy expenditure by transforming calorie-storing white fat into calorie-burning brown fat. Specifically, prominent WAT browning and reduction effects are demonstrated by β3-adrenoceptor agonist and thyroid hormone T3 transdermally delivered from rapidly dissolving MNs on mice. Furthermore, using a diet-induced obese mouse model, it is shown that β3-adrenoceptor agonist released by slowly dissolving MNs can effectively promote WAT browning and suppress gaining of body fat and weight, without the need of daily administration. Such an MN approach can achieve a much lower effective dose as compared to systemic administration and enables long-term home-based treatment.
ISSN: 2366-9608
DOI: 10.1002/smtd.201700269
Rights: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Small Methods, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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