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Title: In vivo studies of transdermal nanoparticle delivery with microneedle using photoacoustic microscopy
Authors: Moothanchery, Mohesh
Seeni, Razina Z.
Xu, Chenjie
Pramanik, Manojit
Keywords: Photoacoustic Imaging
Issue Date: 2017
Source: Moothanchery, M., Seeni, R. Z., Xu, C., & Pramanik, M. (2017). In vivo studies of transdermal nanoparticle delivery with microneedles using photoacoustic microscopy. Biomedical Optics Express, 8(12), 5483-5492.
Series/Report no.: Biomedical Optics Express
Abstract: Microneedle technology allows micron-sized conduits to be formed within the outermost skin layers for both localized and systemic delivery of therapeutics including nanoparticles. Histological methods are often employed for characterization, and unfortunately do not allow for the in vivo visualization of the delivery process. This study presents the utilization of optical resolution-photoacoustic microscopy to characterize the transdermal delivery of nanoparticles using microneedles. Specifically, we observe the in vivo transdermal delivery of gold nanoparticles using microneedles in mice ear and study the penetration, diffusion, and spatial distribution of the nanoparticles in the tissue. The promising results reveal that photoacoustic microscopy can be used as a potential imaging modality for the in vivo characterization of microneedles based drug delivery.
ISSN: 2156-7085
DOI: 10.1364/BOE.8.005483
Rights: © 2017 Optical Society of America. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomedical Optics Express, Optical Society of America. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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