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Title: The regulation of cellular responses to mechanical cues by Rho GTPases
Authors: Hoon, Jing Ling
Tan, Mei Hua
Koh, Cheng-Gee
Keywords: Matrix Stiffness
Rho GTPases
Issue Date: 2016
Source: Hoon, J. L., Tan, M. H., & Koh, C.-G. (2016). The regulation of cellular responses to mechanical cues by Rho GTPases. Cells, 5(2), 17-.
Series/Report no.: Cells
Abstract: The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream effectors. However, cells also respond exquisitely to biophysical and mechanical cues such as stiffness and topography of the extracellular matrix that profoundly influence cell migration, proliferation and differentiation. As these cellular responses are mediated by the actin cytoskeleton, an involvement of Rho GTPases in the transduction of such cues is not unexpected. In this review, we discuss an emerging role of Rho GTPase proteins in the regulation of the responses elicited by biophysical and mechanical stimuli.
ISSN: 2073-4409
DOI: 10.3390/cells5020017
Rights: © 2016 The Author(s); licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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