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https://hdl.handle.net/10356/86530
Title: | Pancreatic Islet Blood Flow Dynamics in Primates | Authors: | Diez, Juan Antonio e Drigo, Rafael Arrojo Zheng, Xiaofeng Stelmashenko, Olga Victoria Chua, Minni Rodriguez-Diaz, Rayner Fukuda, Masahiro Köhler, Martin Leibiger, Ingo Tun, Sai Bo Bo Ali, Yusuf Augustine, George James Barathi, Veluchamy A. Berggren, Per-Olof |
Keywords: | Pancreatic Islet Blood Flow |
Issue Date: | 2017 | Source: | Diez, J. A., e Drigo, R. A., Zheng, X., Stelmashenko, O. V., Chua, M., Rodriguez-Diaz, R., et al. (2017). Pancreatic Islet Blood Flow Dynamics in Primates. Cell Reports, 20(6), 1490-1501. | Series/Report no.: | Cell Reports | Abstract: | Blood flow regulation in pancreatic islets is critical for function but poorly understood. Here, we establish an in vivo imaging platform in a non-human primate where islets transplanted autologously into the anterior chamber of the eye are monitored non-invasively and longitudinally at single-cell resolution. Engrafted islets were vascularized and innervated and maintained the cytoarchitecture of in situ islets in the pancreas. Blood flow velocity in the engrafted islets was not affected by increasing blood glucose levels and/or the GLP-1R agonist liraglutide. However, islet blood flow was dynamic in nature and fluctuated in various capillaries. This was associated with vasoconstriction events resembling a sphincter-like action, most likely regulated by adrenergic signaling. These observations suggest a mechanism in primate islets that diverts blood flow to cell regions with higher metabolic demand. The described imaging technology applied in non-human primate islets may contribute to a better understanding of human islet pathophysiology. | URI: | https://hdl.handle.net/10356/86530 http://hdl.handle.net/10220/44084 |
ISSN: | 2211-1247 | DOI: | 10.1016/j.celrep.2017.07.039 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Organisations: | Nanyang Institute of Structural Biology | Rights: | © 2017 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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Pancreatic Islet Blood Flow Dynamics in Primates.pdf | 3.79 MB | Adobe PDF | View/Open |
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