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Title: A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging
Authors: Jiang, Yuyan
Huang, Jiaguo
Zhen, Xu
Zeng, Ziling
Li, Jingchao
Xie, Chen
Miao, Qingqing
Chen, Jie
Chen, Peng
Pu, Kanyi
Keywords: Nanoparticles
Engineering::Chemical engineering
Issue Date: 2019
Source: Jiang, Y., Huang, J., Zhen, X., Zeng, Z., Li, J., Xie, C., . . . Pu, K. (2019). A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging. Nature Communications, 10(1), 2064-. doi:10.1038/s41467-019-10119-x
Series/Report no.: Nature Communications
Abstract: Afterglow imaging with long-lasting luminescence after cessation of light excitation provides opportunities for ultrasensitive molecular imaging; however, the lack of biologically compatible afterglow agents has impeded exploitation in clinical settings. This study presents a generic approach to transforming ordinary optical agents (including fluorescent polymers, dyes, and inorganic semiconductors) into afterglow luminescent nanoparticles (ALNPs). This approach integrates a cascade photoreaction into a single-particle entity, enabling ALNPs to chemically store photoenergy and spontaneously decay it in an energy-relay process. Not only can the afterglow profiles of ALNPs be finetuned to afford emission from visible to near-infrared (NIR) region, but also their intensities can be predicted by a mathematical model. The representative NIR ALNPs permit rapid detection of tumors in living mice with a signal-to-background ratio that is more than three orders of magnitude higher than that of NIR fluorescence. The biodegradability of the ALNPs further heightens their potential for ultrasensitive in vivo imaging.
DOI: 10.1038/s41467-019-10119-x
Rights: © 2019 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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