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Title: Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins
Authors: Claridge-Chang, Adam
Jesuthasan, Suresh
Mohamed, Gadisti Aisha
Cheng, Ruey-Kuang
Ho, Joses
Krishnan, Seetha
Mohammad, Farhan
Keywords: Optogenetics
Issue Date: 2017
Source: Mohamed, G. A., Cheng, R.-K., Ho, J., Krishnan, S., Mohammad, F., Claridge-Chang, et al. (2017). Optical inhibition of larval zebrafish behaviour with anion channelrhodopsins. BMC Biology, 15(1), 103-.
Series/Report no.: BMC Biology
Abstract: Optical silencing of activity provides a way to test the necessity of neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown to potently inhibit activity in cultured mammalian neurons and in Drosophila. Here, we test the usefulness of these channels in larval zebrafish, using spontaneous coiling behaviour as the assay.
ISSN: 1741-7007
DOI: 10.1186/s12915-017-0430-2
Rights: © 2017 The Author(s) (BioMed Central). This paper was published in BMC Biology and is made available as an electronic reprint (preprint) with permission of The Author(s) (BioMed Central). The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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