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Title: Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation
Authors: Koh, Angela S.
Velmurugan, Bhaarathy
Gao, Fei
Tan, Ru San
Wong, Jia-Ing
Teo, Louis L. Y.
Keng, Bryan M. H.
Chua, Serene J. M.
Yuan, Jian-Min
Koh, Woon-Puay
Cheung, Christine
Keywords: Soluble Urokinase Plasminogen Activator Receptor
Issue Date: 2017
Source: Koh, A. S., Velmurugan, B., Gao, F., Tan, R. S., Wong, J.-I., Teo, L. L. Y., et al. (2017). Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatrics, 17, 275-.
Series/Report no.: BMC Geriatrics
Abstract: Background: SuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predictive biomarker of the ageing heart. Methods: We performed conventional and tissue Doppler echocardiography and measured plasma suPAR levels. Results: We studied community adults (n=120, 37.5% female) (mean age: 70.3±9.3 years) without known cardiovascular disease (CVD). Participants with impaired myocardial relaxation were older (84% vs 59% were aged ≥71 years, p=0.002), with more diabetes mellitus (27% vs 11%, p=0.034). SuPAR levels were higher among participants with impaired myocardial relaxation (3.9 ng/ml vs 3.0 ng/ml, p=0.015). At the univariate level, older age (OR 3.6; 95%CI 1.6, 8.5; p=0.003), diabetes mellitus (OR 3.04; 95%CI 1.1, 8.8; p=0.04), systolic blood pressure (OR 1.03; 95%CI 1.001, 1.1; p=0.041) and suPAR levels ≥3.00ng/ml (OR 3.4; 95%CI 1.16, 7.4; p=0.002) were associated with impaired myocardial relaxation. In multivariable regression analysis, only older age (OR 2.8; 95%CI 1.1, 6.7; p=0.026) and suPAR (OR 2.7; 95%CI 1.2, 6.1; p=0.018) remained independently associated with impaired myocardial relaxation. Receiver operating characteristics (ROC) curve analysis revealed an area under the curve (AUC) value of 0.63 (95% CI 0.54, 0.71) for model that included age alone. Addition of suPAR significantly increased AUC value to 0.70 (95%CI 0.60, 0.79), which was significantly larger than the model with age alone (p=0.016). Conclusion: We demonstrate additional ability of suPAR, over age, to predict impaired myocardial relaxation.
DOI: 10.1186/s12877-017-0668-0
Rights: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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