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Title: Probing Spatial Proximity of Supported Lipid Bilayers to Silica Surfaces by Localized Surface Plasmon Resonance Sensing
Authors: Ferhan, Abdul Rahim
Jackman, Joshua A.
Cho, Nam-Joon
Keywords: Silica
Localized Surface Plasmon Resonance (LSPR)
Issue Date: 2017
Source: Ferhan, A. R., Jackman, J. A., & Cho, N.-J. (2017). Probing Spatial Proximity of Supported Lipid Bilayers to Silica Surfaces by Localized Surface Plasmon Resonance Sensing. Analytical Chemistry, 89(7), 4301-4308.
Series/Report no.: Analytical Chemistry
Abstract: On account of high surface sensitivity, localized surface plasmon resonance (LSPR) sensors have proven widely useful for studying lipid membrane configurations at solid–liquid interfaces. Key measurement capabilities include distinguishing adsorbed vesicles from supported lipid bilayers (SLBs) as well as profiling the extent of deformation among adsorbed vesicles. Such capabilities rely on detecting geometrical changes in lipid membrane configuration on a length scale that is comparable to the decay length of the LSPR-induced electromagnetic field enhancement (∼5–20 nm). Herein, we report that LSPR sensors are also capable of probing nanoscale (∼1 nm) variations in the distance between SLBs and underlying silica-coated surfaces. By tuning the electrostatic properties of lipid membranes, we could modulate the bilayer–substrate interaction and corresponding separation distance, as verified by simultaneous LSPR and quartz crystal microbalance-dissipation (QCM-D) measurements. Theoretical calculations of the expected variation in the LSPR measurement response agree well with experimental results and support that the LSPR measurement response is sensitive to subtle variations in the bilayer–substrate separation distance.
ISSN: 0003-2700
DOI: 10.1021/acs.analchem.7b00370
Rights: © 2017 American Chemical Society (ACS). This is the author created version of a work that has been peer reviewed and accepted for publication by Analytical Chemistry, ACS Publications. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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