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Title: Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons
Authors: Ashokan, Archana
Lim, Jamien Wee Han
Hang, Nicholas
Mitra, Rupshi
Keywords: Medial Prefrontal Cortical Neurons
Dendritic Complexity
Issue Date: 2018
Source: Ashokan, A., Lim, J. W. H., Hang, N., & Mitra, R. (2018). Complex housing causes a robust increase in dendritic complexity and spine density of medial prefrontal cortical neurons. Scientific Reports, 8(1), 7308-.
Series/Report no.: Scientific Reports
Abstract: Prelimbic cortex and infralimbic cortex, parts of the ventromedial prefrontal cortex, are critical brain regions for generating a flexible behavioral response to changing environmental contingencies. This includes the role of these brain structures in the extinction of learned fear, decision making and retrieval of remote memories. Dendritic structure of medial prefrontal cortex neurons retains significant structural plasticity in adulthood. This has been mainly demonstrated as dendritic atrophy and loss of dendritic spines due to chronic stress. It remains unknown if housing condition of the animals itself can cause opposing changes in the dendritic organization. In that backdrop, here we report that short-term increase in complexity of the housing causes a robust increase in complexity of dendritic architecture of prelimbic and infralimbic neurons. This is reflected in the dendritic expansion of prelimbic neurons and increase in spine density of prelimbic and infralimbic neurons. These results suggest that non-invasive changes in the housing environment can be harnessed to study brain reserves for the flexible and species-typical behaviors.
ISSN: 2045-2322
DOI: 10.1038/s41598-018-25399-4
Rights: © 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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