Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87096
Title: Non-invasive sentinel lymph node mapping and needle guidance using clinical handheld photoacoustic imaging system in small animal
Authors: Sivasubramanian, Kathyayini
Periyasamy, Vijitha
Pramanik, Manojit
Keywords: Clinical Photoacoustic System
Fine Needle Aspiration Biopsy
Issue Date: 2017
Source: Sivasubramanian, K., Periyasamy, V., & Pramanik, M. (2018). Non-invasive sentinel lymph node mapping and needle guidance using clinical handheld photoacoustic imaging system in small animal. Journal of Biophotonics, 11(1), e201700061-.
Series/Report no.: Journal of Biophotonics
Abstract: Translating photoacoustic imaging (PAI) into clinical setup is a challenge. Handheld clinical real-time PAI systems are not common. In this work, we report an integrated photoacoustic (PA) and clinical ultrasound imaging system by combining light delivery with the ultrasound probe for sentinel lymph node imaging and needle guidance in small animal. The open access clinical ultrasound platform allows seamless integration of PAI resulting in the development of handheld real-time PAI probe. Both methylene blue and indocyanine green were used for mapping the sentinel lymph node using 675 and 690 nm wavelength illuminations, respectively. Additionally, needle guidance with combined ultrasound and PAI was demonstrated using this imaging system. Up to 1.5 cm imaging depth was observed with a 10 Hz laser at an imaging frame rate of 5 frames per second, which is sufficient for future translation into human sentinel lymph node imaging and needle guidance for fine needle aspiration biopsy.
URI: https://hdl.handle.net/10356/87096
http://hdl.handle.net/10220/44326
ISSN: 1864-063X
DOI: 10.1002/jbio.201700061
Rights: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of Biophotonics, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/jbio.201700061].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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