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dc.contributor.authorMac Aogáin, Micheálen
dc.contributor.authorChandrasekaran, Ravishankaren
dc.contributor.authorLim, Albert Yick Houen
dc.contributor.authorLow, Teck Boonen
dc.contributor.authorTan, Gan Liangen
dc.contributor.authorHassan, Tidien
dc.contributor.authorOng, Thun Howen
dc.contributor.authorBertrand, Denisen
dc.contributor.authorKoh, Jia Yuen
dc.contributor.authorLee, Zi Yangen
dc.contributor.authorGwee, Xiao Weien
dc.contributor.authorMartinus, Christopheren
dc.contributor.authorMatta, Sri Anushaen
dc.contributor.authorChew, Fook Timen
dc.contributor.authorKeir, Holly R.en
dc.contributor.authorAbisheganaden, John Arputhanen
dc.contributor.authorKoh, Mariko Siyueen
dc.contributor.authorNagarajan, Niranjanen
dc.contributor.authorChalmers, James D.en
dc.contributor.authorNg, Amanda Hui Qien
dc.contributor.authorPang, Sze Leien
dc.contributor.authorSio, Yang Yieen
dc.contributor.authorConnolly, John E.en
dc.contributor.authorChotirmall, Sanjay Hareshen
dc.identifier.citationMac Aogáin, M., Chandrasekaran, R., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., . . . Chotirmall, S. H. (2018). Immunological corollary of the pulmonary mycobiome in bronchiectasis : the CAMEB study. European Respiratory Journal, 52(1), 1800766-. doi:10.1183/13993003.00766-2018en
dc.description.abstractUnderstanding the composition and clinical importance of the fungal mycobiome was recently identified as a key topic in a “research priorities” consensus statement for bronchiectasis. Patients were recruited as part of the CAMEB study: an international multicentre cross-sectional Cohort of Asian and Matched European Bronchiectasis patients. The mycobiome was determined in 238 patients by targeted amplicon shotgun sequencing of the 18S–28S rRNA internally transcribed spacer regions ITS1 and ITS2. Specific quantitative PCR for detection of and conidial quantification for a range of airway Aspergillus species was performed. Sputum galactomannan, Aspergillus specific IgE, IgG and TARC (thymus and activation regulated chemokine) levels were measured systemically and associated to clinical outcomes. The bronchiectasis mycobiome is distinct and characterised by specific fungal genera, including Aspergillus, Cryptococcus and Clavispora. Aspergillus fumigatus (in Singapore/Kuala Lumpur) and Aspergillus terreus (in Dundee) dominated profiles, the latter associating with exacerbations. High frequencies of Aspergillus-associated disease including sensitisation and allergic bronchopulmonary aspergillosis were detected. Each revealed distinct mycobiome profiles, and associated with more severe disease, poorer pulmonary function and increased exacerbations. The pulmonary mycobiome is of clinical relevance in bronchiectasis. Screening for Aspergillus-associated disease should be considered even in apparently stable patients.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent14 p.en
dc.relation.ispartofseriesEuropean Respiratory Journalen
dc.rights© 2018 ERS. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.en
dc.subjectCF and Non-CF Bronchiectasisen
dc.subjectPulmonary Mycobiomeen
dc.titleImmunological corollary of the pulmonary mycobiome in bronchiectasis : the CAMEB studyen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.description.versionPublished versionen
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