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Title: Immunological corollary of the pulmonary mycobiome in bronchiectasis : the CAMEB study
Authors: Mac Aogáin, Micheál
Chandrasekaran, Ravishankar
Lim, Albert Yick Hou
Low, Teck Boon
Tan, Gan Liang
Hassan, Tidi
Ong, Thun How
Bertrand, Denis
Koh, Jia Yu
Lee, Zi Yang
Gwee, Xiao Wei
Martinus, Christopher
Matta, Sri Anusha
Chew, Fook Tim
Keir, Holly R.
Abisheganaden, John Arputhan
Koh, Mariko Siyue
Nagarajan, Niranjan
Chalmers, James D.
Ng, Amanda Hui Qi
Pang, Sze Lei
Sio, Yang Yie
Connolly, John E.
Chotirmall, Sanjay Haresh
Keywords: CF and Non-CF Bronchiectasis
Pulmonary Mycobiome
Issue Date: 2018
Source: Mac Aogáin, M., Chandrasekaran, R., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., . . . Chotirmall, S. H. (2018). Immunological corollary of the pulmonary mycobiome in bronchiectasis : the CAMEB study. European Respiratory Journal, 52(1), 1800766-. doi:10.1183/13993003.00766-2018
Series/Report no.: European Respiratory Journal
Abstract: Understanding the composition and clinical importance of the fungal mycobiome was recently identified as a key topic in a “research priorities” consensus statement for bronchiectasis. Patients were recruited as part of the CAMEB study: an international multicentre cross-sectional Cohort of Asian and Matched European Bronchiectasis patients. The mycobiome was determined in 238 patients by targeted amplicon shotgun sequencing of the 18S–28S rRNA internally transcribed spacer regions ITS1 and ITS2. Specific quantitative PCR for detection of and conidial quantification for a range of airway Aspergillus species was performed. Sputum galactomannan, Aspergillus specific IgE, IgG and TARC (thymus and activation regulated chemokine) levels were measured systemically and associated to clinical outcomes. The bronchiectasis mycobiome is distinct and characterised by specific fungal genera, including Aspergillus, Cryptococcus and Clavispora. Aspergillus fumigatus (in Singapore/Kuala Lumpur) and Aspergillus terreus (in Dundee) dominated profiles, the latter associating with exacerbations. High frequencies of Aspergillus-associated disease including sensitisation and allergic bronchopulmonary aspergillosis were detected. Each revealed distinct mycobiome profiles, and associated with more severe disease, poorer pulmonary function and increased exacerbations. The pulmonary mycobiome is of clinical relevance in bronchiectasis. Screening for Aspergillus-associated disease should be considered even in apparently stable patients.
ISSN: 0903-1936
DOI: 10.1183/13993003.00766-2018
Rights: © 2018 ERS. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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