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Title: Feeding Angptl4 −/− mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites
Authors: Oteng, Antwi-Boasiako
Bhattacharya, Asmita
Brodesser, Susanne
Qi, Ling
Tan, Nguan Soon
Kersten, Sander
Keywords: Inflammation
Issue Date: 2017
Source: Oteng, A.-B., Bhattacharya, A., Brodesser, S., Qi, L., Tan, N. S., & Kersten, S. (2017). Feeding Angptl4 −/− mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites. Journal of Lipid Research, 58(6), 1100-1113.
Series/Report no.: Journal of Lipid Research
Abstract: Angiopoietin-like 4 (ANGPTL4) regulates plasma triglyceride levels by inhibiting LPL. Inactivation of ANGPTL4 decreases plasma triglycerides and reduces the risk of coronary artery disease. Unfortunately, targeting ANGPTL4 for the therapeutic management of dyslipidemia and atherosclerosis is hampered by the observation that mice and monkeys in which ANGPTL4 is inactivated exhibit lipid accumulation in the mesenteric lymph nodes (MLNs). In mice these pathological events exclusively unfold upon feeding a high saturated FA diet and are followed by an ultimately lethal pro-inflammatory response and chylous ascites. Here, we show that Angptl4−/− mice fed a diet rich in trans FAs develop numerous lipid-filled giant cells in their MLNs, yet do not have elevated serum amyloid and haptoglobin, do not exhibit ascites, and survive, unlike Angptl4−/− mice fed a saturated FA-rich diet. In RAW264.7 macrophages, the saturated FA, palmitate, markedly increased markers of inflammation and the unfolded protein response, whereas the trans-unsaturated elaidate and the cis-unsaturated oleate had the opposite effect. In conclusion, trans and saturated FAs have very distinct biological effects in macrophages. Furthermore, lipid accumulation in MLNs is uncoupled from activation of an acute-phase response and chylous ascites, suggesting that ANGPTL4 should not be fully dismissed as target for dyslipidemia.
DOI: 10.1194/jlr.M074278
Rights: © 2017 American Society for Biochemistry and Molecular Biology (ASBMB). This paper was published in Journal of Lipid Research and is made available as an electronic reprint (preprint) with permission of American Society for Biochemistry and Molecular Biology (ASBMB). The published version is available at: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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