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Title: ANGPTL4 T266M variant is associated with reduced cancer invasiveness
Authors: Tan, Zhen Wei
Teo, Ziqiang
Tan, Carol
Choo, Chee Chong
Loo, Wei Sheng
Song, Yiyang
Tam, Zhi Yang
Ng, Sean Pin
Koh, Hong Zheng
Ng, Yi Siang
Shochat, Susana Geifman
Yau, Yin Hoe
Zhu, Pengcheng
Tan, Nguan Soon
Keywords: ANGPTL4
Anoikis resistance
Issue Date: 2017
Source: Tan, Z. W., Teo, Z., Tan, C., Choo, C. C., Loo, W. S., Song, Y., et al. (2017). ANGPTL4 T266M variant is associated with reduced cancer invasiveness. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1864(10), 1525-1536.
Series/Report no.: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Abstract: Angiopoietin-like 4 (ANGPTL4) is a secretory protein that can be cleaved to form an N-terminal and a C-terminal protein. Studies performed thus far have linked ANGPTL4 to several cancer-related and metabolic processes. Notably, several point mutations in the C-terminal ANGPTL4 (cANGPTL4) have been reported, although no studies have been performed that ascribed these mutations to cancer-related and metabolic processes. In this study, we compared the characteristics of tumors with and without wild-type (wt) cANGPTL4 and tumors with cANGPTL4 bearing the T266M mutation (T266M cANGPTL4). We found that T266M cANGPTL4 bound to integrin α5β1 with a reduced affinity compared to wt, leading to weaker activation of downstream signaling molecules. The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2. These findings may explain the differences in the tumor characteristics and energy metabolism observed with the cANGPTL4 T266M mutation compared to tumors without the mutation.
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2017.06.010
Rights: © 2017 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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