Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87247
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dc.contributor.authorEsposito, Gianlucaen
dc.contributor.authorHiroi, Noboruen
dc.contributor.authorScattoni, Maria Luisaen
dc.date.accessioned2018-02-02T02:22:26Zen
dc.date.accessioned2019-12-06T16:38:06Z-
dc.date.available2018-02-02T02:22:26Zen
dc.date.available2019-12-06T16:38:06Z-
dc.date.issued2017en
dc.identifier.citationEsposito, G., Hiroi, N., & Scattoni, M. L. (2017). Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder. International Journal of Neuropsychopharmacology, 20(6), 498-503.en
dc.identifier.issn1461-1457en
dc.identifier.urihttps://hdl.handle.net/10356/87247-
dc.description.abstractBackground: Early diagnosis of autism spectrum disorder is critical, because early intensive treatment greatly improves its prognosis. Methods: We review studies that examined vocalizations of infants with autism spectrum disorder and mouse models of autism spectrum disorder as a potential means to identify autism spectrum disorder before the symptomatic elements of autism spectrum disorder emerge. We further discuss clinical implications and future research priorities in the field. Results: Atypical early vocal calls (i.e., cry) may represent an early biomarker for autism spectrum disorder (or at least for a subgroup of children with autism spectrum disorder), and thus can assist with early detection. Moreover, cry is likely more than an early biomarker of autism spectrum disorder; it is also an early causative factor in the development of the disorder. Specifically, atypical crying, as recently suggested, might induce a “self-generated environmental factor” that in turn, influences the prognosis of the disorder. Because atypical crying in autism spectrum disorder is difficult to understand, it may have a negative impact on the quality of care by the caregiver (see graphical abstract). Conclusions: Evidence supports the hypothesis that atypical vocalization is an early, functionally integral component of autism spectrum disorder.en
dc.format.extent6 p.en
dc.language.isoenen
dc.relation.ispartofseriesInternational Journal of Neuropsychopharmacologyen
dc.rights© The Author 2017. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com .en
dc.subjectAutism Spectrum Disorderen
dc.subjectCryen
dc.titleCry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorderen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Humanities and Social Sciencesen
dc.identifier.doi10.1093/ijnp/pyx014en
dc.description.versionPublished versionen
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