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Title: Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder
Authors: Esposito, Gianluca
Hiroi, Noboru
Scattoni, Maria Luisa
Keywords: Autism Spectrum Disorder
Issue Date: 2017
Source: Esposito, G., Hiroi, N., & Scattoni, M. L. (2017). Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder. International Journal of Neuropsychopharmacology, 20(6), 498-503.
Series/Report no.: International Journal of Neuropsychopharmacology
Abstract: Background: Early diagnosis of autism spectrum disorder is critical, because early intensive treatment greatly improves its prognosis. Methods: We review studies that examined vocalizations of infants with autism spectrum disorder and mouse models of autism spectrum disorder as a potential means to identify autism spectrum disorder before the symptomatic elements of autism spectrum disorder emerge. We further discuss clinical implications and future research priorities in the field. Results: Atypical early vocal calls (i.e., cry) may represent an early biomarker for autism spectrum disorder (or at least for a subgroup of children with autism spectrum disorder), and thus can assist with early detection. Moreover, cry is likely more than an early biomarker of autism spectrum disorder; it is also an early causative factor in the development of the disorder. Specifically, atypical crying, as recently suggested, might induce a “self-generated environmental factor” that in turn, influences the prognosis of the disorder. Because atypical crying in autism spectrum disorder is difficult to understand, it may have a negative impact on the quality of care by the caregiver (see graphical abstract). Conclusions: Evidence supports the hypothesis that atypical vocalization is an early, functionally integral component of autism spectrum disorder.
ISSN: 1461-1457
DOI: 10.1093/ijnp/pyx014
Rights: © The Author 2017. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact .
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:HSS Journal Articles

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