Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87385
Title: A novel platform for evaluating the environmental impacts on bacterial cellulose production
Authors: Basu, Anindya
Vadanan, Sundaravadanam Vishnu
Lim, Sierin
Keywords: Bacterial Cellulose (BC)
Biotechnology
Issue Date: 2018
Source: Basu, A., Vadanan, S. V., & Lim, S. (2018). A novel platform for evaluating the environmental impacts on bacterial cellulose production. Scientific Reports, 8(1), 5780-.
Series/Report no.: Scientific Reports
Abstract: Bacterial cellulose (BC) is a biocompatible material with versatile applications. However, its large-scale production is challenged by the limited biological knowledge of the bacteria. The advent of synthetic biology has lead the way to the development of BC producing microbes as a novel chassis. Hence, investigation on optimal growth conditions for BC production and understanding of the fundamental biological processes are imperative. In this study, we report a novel analytical platform that can be used for studying the biology and optimizing growth conditions of cellulose producing bacteria. The platform is based on surface growth pattern of the organism and allows us to confirm that cellulose fibrils produced by the bacteria play a pivotal role towards their chemotaxis. The platform efficiently determines the impacts of different growth conditions on cellulose production and is translatable to static culture conditions. The analytical platform provides a means for fundamental biological studies of bacteria chemotaxis as well as systematic approach towards rational design and development of scalable bioprocessing strategies for industrial production of bacterial cellulose.
URI: https://hdl.handle.net/10356/87385
http://hdl.handle.net/10220/45390
ISSN: 2045-2322
DOI: 10.1038/s41598-018-23701-y
Rights: © 2018 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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