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Title: Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
Authors: Jakobsen, Tim Holm
Tolker-Nielsen, Tim
Givskov, Michael
Keywords: Quorum Sensing
Pseudomonas Aeruginosa
Issue Date: 2017
Source: Jakobsen, T. H., Tolker-Nielsen, T., & Givskov, M. (2017). Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes. International Journal of Molecular Sciences, 18(9), 1970-.
Series/Report no.: International Journal of Molecular Sciences
Abstract: The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has still not been invented and/or developed any simple, efficient and reliable methods with which to “chemically” eradicate biofilm infections. This underlines the resilience of infective agents present as biofilms and it further emphasizes the insufficiency of today’s approaches used to combat chronic infections. A potential method for biofilm dismantling is chemical interception of regulatory processes that are specifically involved in the biofilm mode of life. In particular, bacterial cell to cell signaling called “Quorum Sensing” together with intracellular signaling by bis-(3′-5′)-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. More recently, regulatory processes governed by two component regulatory systems and small non-coding RNAs have been increasingly investigated. Here, we review novel findings and potentials of using small molecules to target and modulate these regulatory processes in the bacterium Pseudomonas aeruginosa to decrease its pathogenic potential.
ISSN: 1661-6596
DOI: 10.3390/ijms18091970
Rights: © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCELSE Journal Articles

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