Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87409
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSikkandhar, Musafar Ganien
dc.contributor.authorNedumaran, Anu Maashaaen
dc.contributor.authorRavichandar, Roopaen
dc.contributor.authorSingh, Satnamen
dc.contributor.authorSanthakumar, Indujaen
dc.contributor.authorGoh, Zheng Congen
dc.contributor.authorMishra, Sachinen
dc.contributor.authorArchunan, Govindarajuen
dc.contributor.authorGulyás, Balázsen
dc.contributor.authorPadmanabhan, Parasuramanen
dc.date.accessioned2018-02-07T04:43:46Zen
dc.date.accessioned2019-12-06T16:41:15Z-
dc.date.available2018-02-07T04:43:46Zen
dc.date.available2019-12-06T16:41:15Z-
dc.date.issued2017en
dc.identifier.citationSikkandhar, M. G., Nedumaran, A. M., Ravichandar, R., Singh, S., Santhakumar, I., Goh, Z. C., et al. (2017). Theranostic Probes for Targeting Tumor Microenvironment: An Overview. International Journal of Molecular Sciences, 18(5), 1036-.en
dc.identifier.issn1661-6596en
dc.identifier.urihttps://hdl.handle.net/10356/87409-
dc.description.abstractLong gone is the time when tumors were thought to be insular masses of cells, residing independently at specific sites in an organ. Now, researchers gradually realize that tumors interact with the extracellular matrix (ECM), blood vessels, connective tissues, and immune cells in their environment, which is now known as the tumor microenvironment (TME). It has been found that the interactions between tumors and their surrounds promote tumor growth, invasion, and metastasis. The dynamics and diversity of TME cause the tumors to be heterogeneous and thus pose a challenge for cancer diagnosis, drug design, and therapy. As TME is significant in enhancing tumor progression, it is vital to identify the different components in the TME such as tumor vasculature, ECM, stromal cells, and the lymphatic system. This review explores how these significant factors in the TME, supply tumors with the required growth factors and signaling molecules to proliferate, invade, and metastasize. We also examine the development of TME-targeted nanotheranostics over the recent years for cancer therapy, diagnosis, and anticancer drug delivery systems. This review further discusses the limitations and future perspective of nanoparticle based theranostics when used in combination with current imaging modalities like Optical Imaging, Magnetic Resonance Imaging (MRI) and Nuclear Imaging (Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT)).en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent27 p.en
dc.language.isoenen
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectNanoparticleen
dc.subjectTumor Microenvironmenten
dc.titleTheranostic Probes for Targeting Tumor Microenvironment: An Overviewen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.3390/ijms18051036en
dc.description.versionPublished versionen
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:LKCMedicine Journal Articles
Files in This Item:
File Description SizeFormat 
Theranostic probes for targeting tumor microenvironment An overview.pdf1.55 MBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 10

44
Updated on Mar 23, 2024

Web of ScienceTM
Citations 10

33
Updated on Oct 28, 2023

Page view(s) 50

575
Updated on Mar 29, 2024

Download(s) 20

210
Updated on Mar 29, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.