Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87430
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dc.contributor.authorTaye, Biruhalemen
dc.contributor.authorYeo, Dawnen
dc.contributor.authorLee, Raphael Tze Chuenen
dc.contributor.authorTan, Boon Huanen
dc.contributor.authorSugrue, Richard J.en
dc.contributor.authorMaurer-Stroh, Sebastianen
dc.date.accessioned2018-02-07T04:33:52Zen
dc.date.accessioned2019-12-06T16:41:42Z-
dc.date.available2018-02-07T04:33:52Zen
dc.date.available2019-12-06T16:41:42Z-
dc.date.issued2017en
dc.identifier.citationTaye, B., Yeo, D., Lee, R. T. C., Tan, B. H., Sugrue, R. J., & Maurer-Stroh, S. (2017). Inter-Species Host Gene Expression Differences in Response to Human and Avian Influenza A Virus Strains. International Journal of Molecular Sciences, 18(11), 2295-.en
dc.identifier.issn1661-6596en
dc.identifier.urihttps://hdl.handle.net/10356/87430-
dc.description.abstractLow pathogenic avian influenza (LPAI) viruses are a source of sporadic human infections and could also contribute to future pandemic outbreaks but little is known about inter-species differences in the host responses to these viruses. Here, we studied host gene expression signatures of cell lines from three species (human, chicken, and canine) in response to six different viruses (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2). Comprehensive microarray probe set re-annotation and ortholog mapping of the host genes was necessary to allow comparison over extended functionally annotated gene sets and orthologous pathways. The annotations are made available to the community for commonly used microarray chips. We observe a strong tendency of the response being cell type- rather than virus-specific. In chicken cells, we found up-regulation of host factors inducing virus infectivity (e.g., oxysterol binding protein like 1A (OSBPL1A) and Rho GTPase activating protein 21 (ARHGAP21)) while reducing apoptosis (e.g., mitochondrial ribosomal protein S27 (MRPS27)) and increasing cell proliferation (e.g., COP9 signalosome subunit 2 (COPS2)). On the other hand, increased antiviral, pro-apoptotic and inflammatory signatures have been identified in human cells while cell cycle and metabolic pathways were down-regulated. This signature describes how low pathogenic avian influenza (LPAI) viruses are being tolerated and shed from chicken but potentially causing cellular disruption in mammalian cells.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent18 p.en
dc.language.isoenen
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectInfluenza A Virusen
dc.subjectApoptosisen
dc.titleInter-Species Host Gene Expression Differences in Response to Human and Avian Influenza A Virus Strainsen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.3390/ijms18112295en
dc.description.versionPublished versionen
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item.grantfulltextopen-
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