Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87431
Title: Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner
Authors: Thion, Morgane Sonia
Low, Donovan
Silvin, Aymeric
Chen, Jinmiao
Grisel, Pauline
Schulte-Schrepping, Jonas
Blecher, Ronnie
Ulas, Thomas
Squarzoni, Paola
Hoeffel, Guillaume
Coulpier, Fanny
Siopi, Eleni
David, Friederike Sophie
Scholz, Claus
Foo, Shihui
Lum, Josephine
Amoyo, Arlaine Anne
Larbi, Anis
Poidinger, Michael
Buttgereit, Anne
Lledo, Pierre-Marie
Greter, Melanie
Chan, Jerry Kok Yen
Amit, Ido
Beyer, Marc
Schultze, Joachim Ludwig
Schlitzer, Andreas
Pettersson, Sven
Ginhoux, Florent
Garel, Sonia
Keywords: CXCR4
Antibiotics
Issue Date: 2017
Source: Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., et al. (2018). Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. Cell, 172(3), 500-516.
Series/Report no.: Cell
Abstract: Microglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults. Antibiotic treatment of adult mice triggered sexually biased microglial responses revealing both acute and long-term effects of microbiota depletion. Finally, human fetal microglia exhibited significant overlap with the murine transcriptomic signature. Our study shows that microglia respond to environmental challenges in a sex- and time-dependent manner from prenatal stages, with major implications for our understanding of microglial contributions to health and disease.
URI: https://hdl.handle.net/10356/87431
http://hdl.handle.net/10220/44422
ISSN: 0092-8674
DOI: 10.1016/j.cell.2017.11.042
Rights: © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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