Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87431
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dc.contributor.authorThion, Morgane Soniaen
dc.contributor.authorLow, Donovanen
dc.contributor.authorSilvin, Aymericen
dc.contributor.authorChen, Jinmiaoen
dc.contributor.authorGrisel, Paulineen
dc.contributor.authorSchulte-Schrepping, Jonasen
dc.contributor.authorBlecher, Ronnieen
dc.contributor.authorUlas, Thomasen
dc.contributor.authorSquarzoni, Paolaen
dc.contributor.authorHoeffel, Guillaumeen
dc.contributor.authorCoulpier, Fannyen
dc.contributor.authorSiopi, Elenien
dc.contributor.authorDavid, Friederike Sophieen
dc.contributor.authorScholz, Clausen
dc.contributor.authorFoo, Shihuien
dc.contributor.authorLum, Josephineen
dc.contributor.authorAmoyo, Arlaine Anneen
dc.contributor.authorLarbi, Anisen
dc.contributor.authorPoidinger, Michaelen
dc.contributor.authorButtgereit, Anneen
dc.contributor.authorLledo, Pierre-Marieen
dc.contributor.authorGreter, Melanieen
dc.contributor.authorChan, Jerry Kok Yenen
dc.contributor.authorAmit, Idoen
dc.contributor.authorBeyer, Marcen
dc.contributor.authorSchultze, Joachim Ludwigen
dc.contributor.authorSchlitzer, Andreasen
dc.contributor.authorPettersson, Svenen
dc.contributor.authorGinhoux, Florenten
dc.contributor.authorGarel, Soniaen
dc.date.accessioned2018-02-09T03:06:30Zen
dc.date.accessioned2019-12-06T16:41:45Z-
dc.date.available2018-02-09T03:06:30Zen
dc.date.available2019-12-06T16:41:45Z-
dc.date.issued2017en
dc.identifier.citationThion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., et al. (2018). Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner. Cell, 172(3), 500-516.en
dc.identifier.issn0092-8674en
dc.identifier.urihttps://hdl.handle.net/10356/87431-
dc.description.abstractMicroglia are embryonically seeded macrophages that contribute to brain development, homeostasis, and pathologies. It is thus essential to decipher how microglial properties are temporally regulated by intrinsic and extrinsic factors, such as sexual identity and the microbiome. Here, we found that microglia undergo differentiation phases, discernable by transcriptomic signatures and chromatin accessibility landscapes, which can diverge in adult males and females. Remarkably, the absence of microbiome in germ-free mice had a time and sexually dimorphic impact both prenatally and postnatally: microglia were more profoundly perturbed in male embryos and female adults. Antibiotic treatment of adult mice triggered sexually biased microglial responses revealing both acute and long-term effects of microbiota depletion. Finally, human fetal microglia exhibited significant overlap with the murine transcriptomic signature. Our study shows that microglia respond to environmental challenges in a sex- and time-dependent manner from prenatal stages, with major implications for our understanding of microglial contributions to health and disease.en
dc.format.extent34 p.en
dc.language.isoenen
dc.relation.ispartofseriesCellen
dc.rights© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectCXCR4en
dc.subjectAntibioticsen
dc.titleMicrobiome Influences Prenatal and Adult Microglia in a Sex-Specific Manneren
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1016/j.cell.2017.11.042en
dc.description.versionPublished versionen
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Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles
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