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Title: Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics
Authors: Li, Jingchao
Zhen, Xu
Lyu, Yan
Jiang, Yuyan
Huang, Jiaguo
Pu, Kanyi
Keywords: DRNTU::Engineering::Chemical engineering
Polymer Nanoparticles
Cell Membrane
Issue Date: 2018
Source: Li, J., Zhen, X., Lyu, Y., Jiang, Y., Huang, J., & Pu, K. (2018). Cell membrane coated semiconducting Polymer Nanoparticles for Enhanced Multimodal Cancer Phototheranostics. ACS Nano, 12(8), 8520-8530. doi:10.1021/acsnano.8b04066
Series/Report no.: ACS Nano
Abstract: Phototheranostic nanoagents are promising for early diagnosis and precision therapy of cancer. However, their imaging ability and therapeutic efficacy are often limited due to the presence of delivery barriers in tumor microenvironment. Herein, we report the development of organic multimodal phototheranostic nanoagents that can biomimetically target cancer-associated fibroblasts in tumor microenvironment for enhanced multimodal imaging-guided cancer therapy. Such biomimetic nanocamouflages comprise a near-infrared (NIR) absorbing semiconducting polymer nanoparticle (SPN) coated with the cell membranes of activated fibroblasts. The homologous targeting mechanism allows the activated fibroblast cell membrane coated SPN (AF-SPN) to specifically target cancer-associated fibroblasts, leading to enhanced tumor accumulation relative to the uncoated and cancer cell membrane coated counterparts after systemic administration in living mice. As such, AF-SPN not only provides stronger NIR fluorescence and photoacoustic (PA) signals to detect tumors, but also generates enhanced cytotoxic heat and single oxygen to exert combinational photothermal and photodynamic therapy, ultimately leading to an antitumor efficacy higher than the counterparts. This study thus introduces an organic phototheranostic system that biomimetically target the component in tumor microenvironment for enhanced multimodal cancer theranostics.
ISSN: 1936-0851
DOI: 10.1021/acsnano.8b04066
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2018 American Chemical Society (ACS). This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Nano, American Chemical Society (ACS). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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