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dc.contributor.authorPosadzki, Pawel Przemyslawen
dc.contributor.authorBajpai, Ramen
dc.contributor.authorKyaw, Bhone Myinten
dc.contributor.authorRoberts, Nicola J.en
dc.contributor.authorBrzezinski, Amnonen
dc.contributor.authorChristopoulos, George Ien
dc.contributor.authorDivakar, Ushashreeen
dc.contributor.authorBajpai, Shwetaen
dc.contributor.authorSoljak, Michaelen
dc.contributor.authorDunleavy, Gerarden
dc.contributor.authorJarbrink, Kristeren
dc.contributor.authorNang, Ei Ei Khaingen
dc.contributor.authorSoh, Chee Kiongen
dc.contributor.authorCar, Josipen
dc.identifier.citationPosadzki, P. P., Bajpai, R., Kyaw, B. M., Roberts, N. J., Brzezinski, A., Christopoulos, G. I., et al. (2018). Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Medicine, 16, 18-.en
dc.description.abstractBACKGROUND: Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved. METHODS: An umbrella review of the evidence across systematic reviews and narrative reviews of endogenous and exogenous (supplementation) MLT was undertaken. The Oxman checklist for assessing the methodological quality of the included systematic reviews was utilised. The following databases were searched: MEDLINE, EMBASE, Web of Science, CENTRAL, PsycINFO and CINAHL. In addition, reference lists were screened. We included reviews of the effects of MLT on any type of health-related outcome measure. RESULTS: Altogether, 195 reviews met the inclusion criteria. Most were of low methodological quality (mean -4.5, standard deviation 6.7). Of those, 164 did not pool the data and were synthesised narratively (qualitatively) whereas the remaining 31 used meta-analytic techniques and were synthesised quantitatively. Seven meta-analyses were significant with P values less than 0.001 under the random-effects model. These pertained to sleep latency, pre-operative anxiety, prevention of agitation and risk of breast cancer. CONCLUSIONS: There is an abundance of reviews evaluating the effects of exogenous and endogenous MLT on health. In general, MLT has been shown to be associated with a wide variety of health outcomes in clinically and methodologically heterogeneous populations. Many reviews stressed the need for more high-quality randomised clinical trials to reduce the existing uncertainties.en
dc.format.extent18 p.en
dc.relation.ispartofseriesBMC Medicineen
dc.rights© The Author(s). 2018 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.titleMelatonin and health: an umbrella review of health outcomes and biological mechanisms of actionen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.contributor.schoolCollege of Business (Nanyang Business School)en
dc.contributor.schoolSchool of Civil and Environmental Engineeringen
dc.description.versionPublished versionen
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