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dc.contributor.authorVenkatesan, Nandinien
dc.contributor.authorWong, Jong Fuen
dc.contributor.authorTan, Kuan Pernen
dc.contributor.authorChung, Hwa Hwaen
dc.contributor.authorYau, Yin Hoeen
dc.contributor.authorCukuroglu, Enginen
dc.contributor.authorAllahverdi, Abdollahen
dc.contributor.authorNordenskiold, Larsen
dc.contributor.authorGoke, Jonathanen
dc.contributor.authorGeifman-Shochat, Susanaen
dc.contributor.authorLin, Valerie Chun Lingen
dc.contributor.authorMadhusudhan, M. S.en
dc.contributor.authorSu, I-hsinen
dc.identifier.citationVenkatesan, N., Wong, J. F., Tan, K. P., Chung, H. H., Yau, Y. H., Cukuroglu, E., et al. (2017). EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms. Oncogene, 37(4), 461-477.en
dc.description.abstractRecently, we reported that the histone methyltransferase, EZH2, controls leukocyte migration through interaction with the cytoskeleton remodeling effector, VAV, and direct methylation of the cytoskeletal regulatory protein, Talin. However, it is unclear whether this extranuclear, epigenetic-independent function of EZH2 has a profound impact on the initiation of cellular transformation and metastasis. Here, we show that EZH2 increases Talin1 methylation and cleavage, thereby enhancing adhesion turnover and promoting accelerated tumorigenesis. This transforming capacity is abolished by targeted disruption of EZH2 interaction with VAV. Furthermore, our studies demonstrate that EZH2 in the cytoplasm is closely associated with cancer stem cell properties, and that overexpression of EZH2, a mutant EZH2 lacking its nuclear localization signal (EZH2ΔNLS), or a methyl-mimicking Talin1 mutant substantially promotes JAK2-dependent STAT3 activation and cellular transformation. Taken together, our results suggest a critical role for the VAV interaction-dependent, extranuclear action of EZH2 in neoplastic transformation.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent71 p.en
dc.rights© 2018 The Author(s) (Nature Publishing Group). This is the author created version of a work that has been peer reviewed and accepted for publication by Oncogene, The Author(s) (Nature Publishing Group). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].en
dc.titleEZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanismsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Computer Science and Engineeringen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.versionAccepted versionen
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