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dc.contributor.authorLiu, Yu-Chien
dc.contributor.authorTeo, Ericia Pei Wenen
dc.contributor.authorAng, Heng Peien
dc.contributor.authorSeah, Xin Yien
dc.contributor.authorLwin, Nyein Chanen
dc.contributor.authorYam, Gary Hin Faien
dc.contributor.authorMehta, Jodhbir Singhen
dc.identifier.citationLiu, Y.-C., Teo, E. P. W., Ang, H. P., Seah, X. Y., Lwin, N. C., Yam, G. H. F., et al. (2018). Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). Scientific Reports, 8(1), 1831-.en
dc.description.abstractCorneal inlays are a relatively new treatment option for presbyopia. Using biological inlays, derived from lenticules extracted from small incision lenticule extraction, may offer advantages over commercialized synthetic inlays in the aspect of biocompatibility. We conducted a non-human primate study to evaluate the safety, predictability, efficacy and tissue response after autogeneic, decellularized xenogeneic and xenogeneic lenticule implantation. The lenticule implantation effectively resulted in central corneal steepening (simulated keratometric values increased by 1.8–2.3 diopters), central hyper-prolate changes (asphericity Q values changed by −0.26 to −0.36), corneal anterior surface elevation (7.7–9.3 μm) and reasonable effective zone (1.5–1.8 times of the lenticule physical diameter), with no differences among the three groups. Slit lamp microscopy, transmission electron microscopy, confocal microscopy, histology and immunohistochemistry analyses confirmed the biocompatibility of the autogeneic and decellularized lenticules, whereas one eye in the xenogeneic group developed corneal stromal rejection during the study period. Our results showed that lenticule implantation has the potential for the management of presbyopia, and provide the basis for future clinical studies. The decellularization process may increase the potential utilization of lenticules without changing the efficacy.en
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent10 p.en
dc.relation.ispartofseriesScientific Reportsen
dc.rights© 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.subjectSmall Incision Lenticule Extractionen
dc.subjectBiological Corneal Inlayen
dc.titleBiological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE)en
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen
dc.description.versionPublished versionen
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