Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87571
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dc.contributor.authorNg, Deborah H. L.en
dc.contributor.authorHo, Hanley J.en
dc.contributor.authorChow, Angelaen
dc.contributor.authorWong, Joshuaen
dc.contributor.authorKyaw, Win Maren
dc.contributor.authorTan, Adrianaen
dc.contributor.authorChia, Po Yingen
dc.contributor.authorChoy, Chiaw Yeeen
dc.contributor.authorTan, Glorijoyen
dc.contributor.authorYeo, Tsin Wenen
dc.contributor.authorLeo, Yee Sinen
dc.date.accessioned2018-07-31T06:26:46Zen
dc.date.accessioned2019-12-06T16:44:42Z-
dc.date.available2018-07-31T06:26:46Zen
dc.date.available2019-12-06T16:44:42Z-
dc.date.issued2018en
dc.identifier.citationNg, D. H. L., Ho, H. J., Chow, A., Wong, J., Kyaw, W. M., Tan, A., et al. (2018). Correlation of clinical illness with viremia in Zika virus disease during an outbreak in Singapore. BMC Infectious Diseases, 18(1), 301-.en
dc.identifier.urihttps://hdl.handle.net/10356/87571-
dc.description.abstractBackground: The first autochthonous Zika virus (ZIKV) outbreak in Singapore was detected in August 2016. We report an analysis of the correlation of clinical illness with viremia and laboratory parameters in this Asian cohort. Methods: We conducted a prospective longitudinal cohort study of patients with a positive blood ZIKV polymerase chain reaction (PCR) result who were admitted to Tan Tock Seng Hospital, Singapore, for isolation and management. Results: We included 40 patients in our study. Rash was present in all patients, while 80% (32/40) had fever, 62.5% (25/40) myalgia, 60% (24/40) conjunctivitis and 38% (15/40) arthralgia. The median duration of viremia was 3.5 days (IQR: 3–5 days). Patients with viremia of ≥4 days were more likely to have prolonged fever compared to those with viremia of less than 4 days (95% versus 63%, p=0.01), but had no significant correlation with other clinical signs and symptoms, or laboratory investigations. However, 21 patients (53%) had hypokalemia despite the absence of gastrointestinal symptoms. Conclusion: Although fever correlated with duration of viremia, 30% of patients remained viremic despite defervescence. Laboratory abnormalities such as leukopenia or thrombocytopenia were not prominent in this cohort but about half the patients were noted to have hypokalemia.en
dc.format.extent7 p.en
dc.language.isoenen
dc.relation.ispartofseriesBMC Infectious Diseasesen
dc.rights© 2018 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectViremiaen
dc.subjectZikaen
dc.titleCorrelation of clinical illness with viremia in Zika virus disease during an outbreak in Singaporeen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.1186/s12879-018-3211-9en
dc.description.versionPublished versionen
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Appears in Collections:LKCMedicine Journal Articles

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