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Title: The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes
Authors: Chua, Jacqueline
Chia, Ai-Ru
Chee, Miao Li
Man, Ryan Eyn Kidd
Tan, Gavin Siew Wei
Lamoureux, Ecosse L.
Wong, Tien Yin
Chong, Mary Foong-Fong
Schmetterer, Leopold
Keywords: Diabetic Retinopathy (DR)
Retinal Vascular Caliber
Issue Date: 2018
Source: Chua, J., Chia, A.-R., Chee, M. L., Man, R. E. K., Tan, G. S. W., Lamoureux, E. L., et al. (2018). The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes. Scientific Reports, 8(1), 730-.
Series/Report no.: Scientific Reports
Abstract: In this cross-sectional study, we evaluated the association of dietary fish intake with varying severity of diabetic retinopathy (DR) and retinal vascular caliber in Asians with type 2 diabetes mellitus. 357 Asians (median age: 58 years; 31% women; 78% Chinese) were recruited from a tertiary eye care institution in Singapore. Fish consumption was evaluated using a validated food frequency questionnaire. Digital retinal photographs assessed for DR severity and retinal vascular caliber. Ordered logistic and linear regression models were used to investigate the association of fish intake with DR severity and vascular caliber. Increasing frequency of fish consumption was significantly associated with lower odds of having severe DR (odds ratio [OR]=0.91, 95% CI: 0.84–0.99 per 1-unit increase of fish intake; P=0.038). Among those with no retinopathy, persons in quartile 4 fish intake had a wider retinal vascular caliber for arteriolar (β=22.27 µm, 95% CI: 12.64–31.90; P-trend < 0.001) and venular (β=32.00 µm, 95% CI: 17.56–46.43; P-trend < 0.001), than those in quartile 1 fish intake. Persons with higher fish intake had a decreased likelihood of having severe DR. In diabetics without retinopathy, higher fish intake was associated with wider retinal vascular caliber. Future research is needed to reinforce the direction of the casualty.
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18930-6
Rights: © 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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