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Title: Neutralizing antibodies against plasmodium falciparum associated with successful cure after drug therapy
Authors: Goh, Yun Shan
Peng, Kaitian
Chia, Wan Ni
Siau, Anthony
Chotivanich, Kesinee
Gruner, Anne-Charlotte
Preiser, Peter
Mayxay, Mayfong
Pukrittayakamee, Sasithon
Sriprawat, Kanlaya
Nosten, Francois
White, Nicholas J.
Renia, Laurent
Keywords: Antibody Response
DRNTU::Science::Biological sciences
Malaria, Falciparum
Issue Date: 2016
Source: Goh, Y. S., Peng, K., Chia, W. N., Siau, A., Chotivanich, K., Gruner, A.-C., . . . Renia, L. (2016). Neutralizing antibodies against plasmodium falciparum associated with successful cure after drug therapy. PLOS ONE, 11(7), e0159347-. doi:10.1371/journal.pone.0159347
Series/Report no.: PLOS ONE
Abstract: An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. To examine this, sera were obtained from two groups of adult patients with acute falciparum malaria, prior to drug treatment: patients who (1) have subsequent recrudescent infection, or (2) were cured by Day 28 following treatment. Using a Plasmodium falciparum antigen library, we examined the antibody specificities in these sera. While the antibody repertoire of both sera groups was extremely broad and varied, there was a differential antibody profile between the two groups of sera. The proportion of cured patients with antibodies against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 was higher than the proportion of patients with recrudescent infection. The presence of these antibodies was associated with higher odds of treatment cure. Sera containing all six antibodies impaired the invasion of P. falciparum clinical isolates into erythrocytes. These results suggest that antibodies specific against EXP1, MSP3, GLURP, RAMA, SEA and EBA181 in P. falciparum infections could assist anti-malarial drug treatment and contribute to the resolution of the malarial infection.
DOI: 10.1371/journal.pone.0159347
Rights: © 2016 Goh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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