Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87776
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dc.contributor.authorTan, Nguan Soonen
dc.contributor.authorWahli, Walteren
dc.contributor.authorChen, Jiapengen
dc.contributor.authorMontagner, Alexandraen
dc.date.accessioned2018-08-08T01:53:51Zen
dc.date.accessioned2019-12-06T16:49:16Z-
dc.date.available2018-08-08T01:53:51Zen
dc.date.available2019-12-06T16:49:16Z-
dc.date.issued2018en
dc.identifier.citationChen, J., Montagner, A., Tan, N. S., & Wahli, W. (2018). Insights into the Role of PPARβ/δ in NAFLD. International Journal of Molecular Sciences, 19(7), 1893-.en
dc.identifier.issn1661-6596en
dc.identifier.urihttps://hdl.handle.net/10356/87776-
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries. Although usually associated with obesity, NAFLD is also diagnosed in individuals with low body mass index (BMI) values, especially in Asia. NAFLD can progress from steatosis to non-alcoholic steatohepatitis (NASH), which is characterized by liver damage and inflammation, leading to cirrhosis and hepatocellular carcinoma (HCC). NAFLD development can be induced by lipid metabolism alterations; imbalances of pro- and anti-inflammatory molecules; and changes in various other factors, such as gut nutrient-derived signals and adipokines. Obesity-related metabolic disorders may be improved by activation of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)β/δ, which is involved in metabolic processes and other functions. This review is focused on research findings related to PPARβ/δ-mediated regulation of hepatic lipid and glucose metabolism and NAFLD development. It also discusses the potential use of pharmacological PPARβ/δ activation for NAFLD treatment.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent23 p.en
dc.language.isoenen
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2018 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectPPARβ/δen
dc.subjectNAFLDen
dc.titleInsights into the role of PPARβ/δ in NAFLDen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.3390/ijms19071893en
dc.description.versionPublished versionen
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Appears in Collections:LKCMedicine Journal Articles
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