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Title: Insights into the role of PPARβ/δ in NAFLD
Authors: Tan, Nguan Soon
Wahli, Walter
Chen, Jiapeng
Montagner, Alexandra
Keywords: PPARβ/δ
Issue Date: 2018
Source: Chen, J., Montagner, A., Tan, N. S., & Wahli, W. (2018). Insights into the Role of PPARβ/δ in NAFLD. International Journal of Molecular Sciences, 19(7), 1893-.
Series/Report no.: International Journal of Molecular Sciences
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a major health issue in developed countries. Although usually associated with obesity, NAFLD is also diagnosed in individuals with low body mass index (BMI) values, especially in Asia. NAFLD can progress from steatosis to non-alcoholic steatohepatitis (NASH), which is characterized by liver damage and inflammation, leading to cirrhosis and hepatocellular carcinoma (HCC). NAFLD development can be induced by lipid metabolism alterations; imbalances of pro- and anti-inflammatory molecules; and changes in various other factors, such as gut nutrient-derived signals and adipokines. Obesity-related metabolic disorders may be improved by activation of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)β/δ, which is involved in metabolic processes and other functions. This review is focused on research findings related to PPARβ/δ-mediated regulation of hepatic lipid and glucose metabolism and NAFLD development. It also discusses the potential use of pharmacological PPARβ/δ activation for NAFLD treatment.
ISSN: 1661-6596
DOI: 10.3390/ijms19071893
Rights: © 2018 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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