Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87777
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dc.contributor.authorBrunmeir, Reinharden
dc.contributor.authorXu, Fengen
dc.date.accessioned2018-08-08T01:37:08Zen
dc.date.accessioned2019-12-06T16:49:17Z-
dc.date.available2018-08-08T01:37:08Zen
dc.date.available2019-12-06T16:49:17Z-
dc.date.issued2018en
dc.identifier.citationBrunmeir, R., & Xu, F. (2018). Functional regulation of ppars through post-translational modifications. International Journal of Molecular Sciences, 19(6), 1738-.en
dc.identifier.issn1661-6596en
dc.identifier.urihttps://hdl.handle.net/10356/87777-
dc.description.abstractPeroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily and they are essential regulators of cell differentiation, tissue development, and energy metabolism. Given their central roles in sensing the cellular metabolic state and controlling metabolic homeostasis, PPARs became important targets of drug development for the management of metabolic disorders. The function of PPARs is mainly regulated through ligand binding, which induces structural changes, further affecting the interactions with co-activators or co-repressors to stimulate or inhibit their functions. In addition, PPAR functions are also regulated by various Post-translational modifications (PTMs). These PTMs include phosphorylation, SUMOylation, ubiquitination, acetylation, and O-GlcNAcylation, which are found at numerous modification sites. The addition of these PTMs has a wide spectrum of consequences on protein stability, transactivation function, and co-factor interaction. Moreover, certain PTMs in PPAR proteins have been associated with the status of metabolic diseases. In this review, we summarize the PTMs found on the three PPAR isoforms PPARα, PPARβ/δ, and PPARγ, and their corresponding modifying enzymes. We also discuss the functional roles of these PTMs in regulating metabolic homeostasis and provide a perspective for future research in this intriguing field.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.format.extent16 p.en
dc.language.isoenen
dc.relation.ispartofseriesInternational Journal of Molecular Sciencesen
dc.rights© 2018 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectPPARaen
dc.subjectNuclear Receptorsen
dc.titleFunctional regulation of ppars through post-translational modificationsen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doi10.3390/ijms19061738en
dc.description.versionPublished versionen
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Appears in Collections:LKCMedicine Journal Articles
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