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Title: Choroidal remodeling in age-related macular degeneration and polypoidal choroidal vasculopathy : a 12-month prospective study
Authors: Ting, Daniel Shu Wei
Yanagi, Yasuo
Agrawal, Rupesh
Teo, Hwei Yee
Seen, Sophia
Yeo, Ian Yew San
Mathur, Ranjana
Chan, Choi Mun
Lee, Shu Yen
Wong, Edmund Yick Mun
Wong, Doric
Wong, Tien Yin
Cheung, Gemmy Chui Ming
Keywords: Choroid
Age-related Macular Degeneration
Issue Date: 2017
Source: Ting, D. S. W., Yanagi, Y., Agrawal, R., Teo, H. Y., Seen, S., Yeo, I. Y. S., . . . Cheung, G. C. M. (2017). Choroidal remodeling in age-related macular degeneration and polypoidal choroidal vasculopathy : a 12-month prospective study. Scientific Reports, 7, 7868-. doi:10.1038/s41598-017-08276-4
Series/Report no.: Scientific Reports
Abstract: Choroid thinning occurs in age-related macular degeneration (AMD). However, it remains unclear whether the reduction is due to reduction in choroidal vessels or shrinkage of choroidal stroma, or both. The purpose of this study was to evaluate the changes of the choroidal vascular and stromal area in 118 patients with typical AMD (t-AMD) and polypoidal choroidal vasculopathy (PCV) over a 12-month period. We used spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode to measure the subfoveal choroidal thickness (CT), central retinal thickness (CRT) and choroidal vascularity index (CVI - ratio of luminal area to total choroidal area). At baseline, PCV eyes had higher CRT (471.6 µm vs 439.1 µm, p = 0.02), but comparable subfoveal CT and CVI, compared to t-AMD. Eyes with high CVI at baseline showed marked reduction in stromal area compared with eyes with average or low CVI. Over 12 months, CRT and subfoveal CT significantly decreased (p < 0.001) in both subtypes. Eyes with high baseline CVI showed significant CVI reduction from baseline to month 12 (p < 0.001), whereas eyes with average to low baseline CVI showed increase in CVI. These differences in choroidal vascularity may reflect different predominant pathogenic processes and remodeling in AMD eyes with varying spectrum.
DOI: 10.1038/s41598-017-08276-4
Rights: © 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles


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