Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87984
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dc.contributor.authorChalmers, James Den
dc.contributor.authorChotirmall, Sanjay Hareshen
dc.date.accessioned2018-03-05T08:53:42Zen
dc.date.accessioned2019-12-06T16:53:30Z-
dc.date.available2018-03-05T08:53:42Zen
dc.date.available2019-12-06T16:53:30Z-
dc.date.issued2018en
dc.identifier.citationChalmers, J. D., & Chotirmall, S. H. (2018). Bronchiectasis: new therapies and new perspectives. The Lancet Respiratory Medicine, in press.en
dc.identifier.issn2213-2600en
dc.identifier.urihttps://hdl.handle.net/10356/87984-
dc.identifier.urihttp://hdl.handle.net/10220/44510en
dc.description.abstractEuropean Respiratory Society guidelines for the management of adult bronchiectasis highlight the paucity of treatment options available for patients with this disorder. No treatments have been licensed by regulatory agencies worldwide, and most therapies used in clinical practice are based on very little evidence. Development of new treatments is needed urgently. We did a systematic review of scientific literature and clinical trial registries to identify agents in early-to-late clinical development for bronchiectasis in adults. In this Review, we discuss the mechanisms and potential roles of emerging therapies, including drugs that target airway and systemic inflammation, mucociliary clearance, and epithelial dysfunction. To ensure these treatments achieve success in randomised clinical trials-and therefore reach patients-we propose a reassessment of the current approach to bronchiectasis. Although understanding of the pathophysiology of bronchiectasis is at an early stage, we argue that bronchiectasis is a heterogeneous disease with many different biological mechanisms that drive disease progression (endotypes), and therefore the so-called treatable traits approach used in asthma and chronic obstructive pulmonary disease could be applied to bronchiectasis, with future trials targeted at the specific disease subgroups most likely to benefit.en
dc.language.isoenen
dc.relation.ispartofseriesThe Lancet Respiratory Medicineen
dc.rights© 2018 Elsevier Ltd.en
dc.subjectTherapiesen
dc.subjectBronchiectasisen
dc.titleBronchiectasis: new therapies and new perspectivesen
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.identifier.doihttp://dx.doi.org/10.1016/S2213-2600(18)30053-5en
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:LKCMedicine Journal Articles

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