Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/87995
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLow, Aloysius Y. T.en
dc.contributor.authorThanawalla, Ayesha Rustomen
dc.contributor.authorYip, Alaric K. K.en
dc.contributor.authorKim, Jinsooken
dc.contributor.authorWong, Kelly L. L.en
dc.contributor.authorTantra, Martesaen
dc.contributor.authorAugustine, George Jamesen
dc.contributor.authorChen, Albert I-Mingen
dc.date.accessioned2018-03-05T05:46:41Zen
dc.date.accessioned2019-12-06T16:53:44Z-
dc.date.available2018-03-05T05:46:41Zen
dc.date.available2019-12-06T16:53:44Z-
dc.date.issued2018en
dc.identifier.citationLow, A. Y. T., Thanawalla, A. R., Yip, A. K. K., Kim, J., Wong, K. L. L., Tantra, M., et al. (2018). Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus. Cell Reports, 22(9), 2322-2333.en
dc.identifier.issn2211-1247en
dc.identifier.urihttps://hdl.handle.net/10356/87995-
dc.identifier.urihttp://hdl.handle.net/10220/44499en
dc.description.abstractThe deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable population of neurons in the mouse interposed anterior nucleus (IntA). We show that these neurons represent a subset of glutamatergic neurons in the IntA and constitute a specific element of an internal feedback circuit within the cerebellar cortex and cerebello-thalamo-cortical pathway associated with limb control. Ablation and optogenetic stimulation of these neurons disrupt efficacy of skilled reach and locomotor movement and reveal that they control positioning and timing of the forelimb and hindlimb. Together, our findings uncover the function of a distinct neuronal subpopulation in the deep cerebellum and delineate the anatomical substrates and kinematic parameters through which it modulates precision of discrete and rhythmic limb movements.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent12 p.en
dc.language.isoenen
dc.relation.ispartofseriesCell Reportsen
dc.rights© 2018 The Author(s) (Published by Elsevier). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.subjectDCNen
dc.subjectIntAen
dc.titlePrecision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleusen
dc.typeJournal Articleen
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doihttp://dx.doi.org/10.1016/j.celrep.2018.02.017en
dc.description.versionPublished versionen
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles
SBS Journal Articles

Google ScholarTM

Check

Altmetric

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.