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Title: Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus
Authors: Low, Aloysius Y. T.
Thanawalla, Ayesha Rustom
Yip, Alaric K. K.
Kim, Jinsook
Wong, Kelly L. L.
Tantra, Martesa
Augustine, George James
Chen, Albert I-Ming
Keywords: DCN
Issue Date: 2018
Source: Low, A. Y. T., Thanawalla, A. R., Yip, A. K. K., Kim, J., Wong, K. L. L., Tantra, M., et al. (2018). Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus. Cell Reports, 22(9), 2322-2333.
Series/Report no.: Cell Reports
Abstract: The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable population of neurons in the mouse interposed anterior nucleus (IntA). We show that these neurons represent a subset of glutamatergic neurons in the IntA and constitute a specific element of an internal feedback circuit within the cerebellar cortex and cerebello-thalamo-cortical pathway associated with limb control. Ablation and optogenetic stimulation of these neurons disrupt efficacy of skilled reach and locomotor movement and reveal that they control positioning and timing of the forelimb and hindlimb. Together, our findings uncover the function of a distinct neuronal subpopulation in the deep cerebellum and delineate the anatomical substrates and kinematic parameters through which it modulates precision of discrete and rhythmic limb movements.
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2018.02.017
Rights: © 2018 The Author(s) (Published by Elsevier). This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles
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