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dc.contributor.authorWong, De Weien
dc.contributor.authorGan, Wei Liangen
dc.contributor.authorLiu, Ningen
dc.contributor.authorLew, Wen Siangen
dc.identifier.citationWong, D. W., Gan, W. L., Liu, N., & Lew, W. S. (2017). Magneto-actuated cell apoptosis by biaxial pulsed magnetic field. Scientific Reports, 7, 10919-. doi:10.1038/s41598-017-11279-wen
dc.description.abstractWe report on a highly efficient magneto-actuated cancer cell apoptosis method using a biaxial pulsed magnetic field configuration, which maximizes the induced magnetic torque. The light transmissivity dynamics show that the biaxial magnetic field configuration can actuate the magnetic nanoparticles with higher responsiveness over a wide range of frequencies as compared to uniaxial field configurations. Its efficacy was demonstrated in in vitro cell destruction experiments with a greater reduction in cell viability. Magnetic nanoparticles with high aspect ratios were also found to form a triple vortex magnetization at remanence which increases its low field susceptibility. This translates to a larger magneto-mechanical actuated force at low fields and 12% higher efficacy in cell death as compared to low aspect ratio nanoparticles.en
dc.description.sponsorshipMOE (Min. of Education, S’pore)en
dc.format.extent8 p.en
dc.relation.ispartofseriesScientific Reportsen
dc.rights© 2017 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.subjectMagnetic Fielden
dc.subjectCell Apoptosisen
dc.titleMagneto-actuated cell apoptosis by biaxial pulsed magnetic fielden
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.description.versionPublished versionen
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