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Title: Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy
Authors: Witkowska, Katarzyna J.
Bata, Ahmed M.
Calzetti, Giacomo
Luft, Nikolaus
Fondi, Klemens
Wozniak, Piotr A.
Schmidl, Doreen
Bolz, Matthias
Popa-Cherecheanu, Alina
Werkmeister, René M.
Garhöfer, Gerhard
Schmetterer, Leopold
Keywords: Blood Flowmetry
Intraocular Pressure
Issue Date: 2017
Source: Witkowska, K. J., Bata, A. M., Calzetti, G., Luft, N., Fondi, K., Wozniak, P. A., et al. (2017). Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy. PLOS ONE, 12(9), e0184772-.
Series/Report no.: PLOS ONE
Abstract: The aim of the present study was to investigate regulation of blood flow (BF) in the optic nerve head (ONH) and a peripapillary region (PPR) during an isometric exercise-induced increase in ocular perfusion pressure (OPP) using laser speckle flowgraphy (LSFG) in healthy subjects. For this purpose, a total of 27 subjects was included in this study. Mean blur rate in tissue (MT) was measured in the ONH and in a PPR as well as relative flow volume (RFV) in retinal arteries (ART) and veins (VEIN) using LSFG. All participants performed isometric exercise for 6 minutes during which MT and mean arterial pressure were measured every minute. From these data OPP and pressure/flow curves were calculated. Isometric exercise increased OPP, MTONH and MTPRR. The relative increase in OPP (78.5 ± 19.8%) was more pronounced than the increase in BF parameters (MTONH: 18.1 ± 7.7%, MTPRR: 21.1 ± 8.3%, RFVART: 16.5 ±12.0%, RFVVEIN: 17.7 ± 12.4%) indicating for an autoregulatory response of the vasculature. The pressure/flow curves show that MTONH, MTPRR, RFVART, RFVVEIN started to increase at OPP levels of 51.2 ± 2.0%, 58.1 ± 2.4%, 45.6 ± 1.9% and 45.6 ± 1.9% above baseline. These data indicate that ONHBF starts to increase at levels of approx. 50% increase in OPP: This is slightly lower than the values we previously reported from LDF data. Signals from the PPR may have input from both, the retina and the choroid, but the relative contribution is unknown. In addition, retinal BF appears to increase at slightly lower OPP values of approximately 45%. LSFG may be used to study ONH autoregulation in diseases such as glaucoma.
DOI: 10.1371/journal.pone.0184772
Rights: © 2017 Witkowska et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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