Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88205
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLiu, Yu-Chien
dc.contributor.authorNg, Anthony Herr Cheunen
dc.contributor.authorNg, Xu Wenen
dc.contributor.authorYan, Pengen
dc.contributor.authorVenkatraman, Subbu Subramanianen
dc.contributor.authorMehta, Jodhbir Singhen
dc.contributor.authorWong, Tina Tzee Lingen
dc.date.accessioned2018-03-16T07:04:34Zen
dc.date.accessioned2019-12-06T16:58:15Z-
dc.date.available2018-03-16T07:04:34Zen
dc.date.available2019-12-06T16:58:15Z-
dc.date.copyright2017en
dc.date.issued2017en
dc.identifier.citationLiu, Y.-C., Ng, A. H. C., Ng, X. W., Yan, P., Venkatraman, S. S., Mehta, J. S., et al. (2017). Evaluation of a Sustained-Release Prednisolone Acetate Biodegradable Subconjunctival Implant in a Non-Human Primate Model. Translational Vision Science & Technology, 6(5), 9-.en
dc.identifier.urihttps://hdl.handle.net/10356/88205-
dc.description.abstractPurpose: We evaluate the toxicity and plasma toxicokinetic (TK) profile of a biodegradable subconjunctival microrod for sustained prednisolone acetate (PA) release over 12 weeks in a non-human primate model. Methods: The biodegradable copolymer poly(l-lactide-co-ε-caprolactone) (PLC) and 40-wt% PA microrods were used and fashioned into 8 and 16 mm lengths. Twelve monkeys were divided into two treatment groups of PA-loaded and blank microrods, with six monkeys each receiving either 8- or 16-mm microrods subconjunctively implanted into both eyes. TK and hematology parameters were analyzed. Ophthalmic clinical evaluation, including slit-lamp and ophthalmoscopy examinations, was performed. Results: Over the study period of 12 weeks, the mean area under the plasma concentration-time curve was 45.7% higher, and the maximum plasma concentration was 17.2% lower for the animals treated with 40-wt% PA 16-mm microrods compared to 8-mm microrods (251.44 versus 172.54 hours × nanograms per milliliter and 8.53 versus 10.30 ng/mL, respectively). The PA release was significantly below the levels of assumed toxicity. There was no significant difference in the time to reach maximum concentration between the 8- and 16-mm microrod groups (7.33 and 8 hours; P = 0.421). Findings from clinical evaluation, hematology, and histopathology showed no ocular side effects and no significant adverse systemic effects. Conclusion: The PA biodegradable microrods demonstrated safe toxicokinetics even with the larger size implant containing a higher amount of drug. The PA implant may be considered as a safe alternative to the application of topical PA eyedrops. Translational Relevance: The results provide the evidence of the safety of implanting a steroid delivery system subconjunctively, offering an alternative to topical PA eyedrops.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.description.sponsorshipMOH (Min. of Health, S’pore)en
dc.format.extent7 p.en
dc.language.isoenen
dc.relation.ispartofseriesTranslational Vision Science & Technologyen
dc.rights© 2017 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.en
dc.subjectDrug Deliveryen
dc.subjectSubconjunctivalen
dc.titleEvaluation of a Sustained-release Prednisolone Acetate Biodegradable Subconjunctival Implant in a Non-Human Primate Modelen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.identifier.doi10.1167/tvst.6.5.9en
dc.description.versionPublished versionen
dc.identifier.rims203630en
item.grantfulltextopen-
item.fulltextWith Fulltext-
Appears in Collections:MSE Journal Articles
Files in This Item:
File Description SizeFormat 
Evaluation of a Sustained-Release Prednisolone Acetate.pdf742.24 kBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 20

4
Updated on Mar 8, 2021

PublonsTM
Citations 20

5
Updated on Mar 9, 2021

Page view(s)

174
Updated on Sep 17, 2021

Download(s) 50

61
Updated on Sep 17, 2021

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.