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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, Hui Ling | en |
dc.date.accessioned | 2018-09-05T02:49:11Z | en |
dc.date.accessioned | 2019-12-06T16:58:35Z | - |
dc.date.available | 2018-09-05T02:49:11Z | en |
dc.date.available | 2019-12-06T16:58:35Z | - |
dc.date.issued | 2018 | en |
dc.identifier.citation | Chan, H. L. (2018). Development of small molecule probe for screening of bacterial resistant enzyme and their biomedical applications. Master's thesis, Nanyang Technological University, Singapore. | en |
dc.identifier.uri | https://hdl.handle.net/10356/88224 | - |
dc.description.abstract | The work in this thesis has been aimed towards development of a small molecular probe for the screening of bacterial resistant enzymes. This thesis is divided into three main parts. Part I incorporates an introduction to gram positive and negative bacteria and its cell structure, β-lactam antibiotics with a brief insight into various core structure that drugs commonly consist of, β-lactamase enzyme mechanisms and the classifications, recent development in the use of small molecular probe for β-lactamase activities monitoring and imaging, as well as the current gaps and proposed work. Part II disclosed on a covalent labelling approach towards imaging AmpC β-lactamase activity on bacteria cell wall. Part III encloses the experimental data and references (Chapter III). | en |
dc.format.extent | 68 p. | en |
dc.language.iso | en | en |
dc.subject | DRNTU::Science::Chemistry | en |
dc.title | Development of small molecule probe for screening of bacterial resistant enzyme and their biomedical applications | en |
dc.type | Thesis | en |
dc.contributor.supervisor | Xing Bengang | en |
dc.contributor.school | School of Physical and Mathematical Sciences | en |
dc.description.degree | Master of Science | en |
dc.identifier.doi | 10.32657/10220/45819 | en |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | SPMS Theses |
Files in This Item:
File | Description | Size | Format | |
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Development of Small Molecule Probe for Screening of Bacterial Resistant Enzyme and their Biomedical Applications.pdf | 2.29 MB | Adobe PDF | View/Open |
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