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|Title:||Development of small molecule probe for screening of bacterial resistant enzyme and their biomedical applications||Authors:||Chan, Hui Ling||Keywords:||DRNTU::Science::Chemistry||Issue Date:||2018||Source:||Chan, H. L. (2018). Development of small molecule probe for screening of bacterial resistant enzyme and their biomedical applications. Master's thesis, Nanyang Technological University, Singapore.||Abstract:||The work in this thesis has been aimed towards development of a small molecular probe for the screening of bacterial resistant enzymes. This thesis is divided into three main parts. Part I incorporates an introduction to gram positive and negative bacteria and its cell structure, β-lactam antibiotics with a brief insight into various core structure that drugs commonly consist of, β-lactamase enzyme mechanisms and the classifications, recent development in the use of small molecular probe for β-lactamase activities monitoring and imaging, as well as the current gaps and proposed work. Part II disclosed on a covalent labelling approach towards imaging AmpC β-lactamase activity on bacteria cell wall. Part III encloses the experimental data and references (Chapter III).||URI:||https://hdl.handle.net/10356/88224
|DOI:||10.32657/10220/45819||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Theses|
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