The current status of 3D bioprinting for neural tissue models

Abstract

Neurological disease is one of the devastating diseases worldwide. Limited regeneration capability of central nervous system has greatly hindered the functional recovery of neural tissues. Bioprinting, offers a promising method to deposit cells, materials and instructive biomolecules in a precise arrangement simultaneously, which is possible to achieve the construction of multicellular functional neural tissues. In this review, we have 1) identified the essential design parameters of neural tissue constructs based on native tissue contexts 2) reviewed the updated studies of bioprinting for neural tissue applications 3) discussed the challenges and prospects of bioprinting for neural tissue development.