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Title: ZnO nano-rod devices for intradermal delivery and immunization
Authors: Nayak, Tapas R.
Wang, Hao
Pant, Aakansha
Zheng, Minrui
Junginger, Hans
Goh, Wei Jiang
Lee, Choon Keong
Zou, Shui
Alonso, Sylvie
Czarny, Bertrand
Storm, Gert
Sow, Chorng Haur
Chengkuo, Lee
Pastorin, Giorgia
Keywords: DRNTU::Engineering::Materials
ZnO Nano-rods
Skin Immunization
Issue Date: 2017
Source: Nayak, T. R., Wang, H., Pant, A., Zheng, M., Junginger, H., Goh, W. J., . . . Pastorin, G. (2017). ZnO Nano-Rod Devices for Intradermal Delivery and Immunization. Nanomaterials, 7(6), 147-. doi:10.3390/nano7060147
Series/Report no.: Nanomaterials
Abstract: Intradermal delivery of antigens for vaccination is a very attractive approach since the skin provides a rich network of antigen presenting cells, which aid in stimulating an immune response. Numerous intradermal techniques have been developed to enhance penetration across the skin. However, these methods are invasive and/or affect the skin integrity. Hence, our group has devised zinc oxide (ZnO) nano-rods for non-destructive drug delivery. Chemical vapour deposition was used to fabricate aligned nano-rods on ZnO pre-coated silicon chips. The nano-rods’ length and diameter were found to depend on the temperature, time, quality of sputtered silicon chips, etc. Vertically aligned ZnO nano-rods with lengths of 30–35 µm and diameters of 200–300 nm were selected for in vitro human skin permeation studies using Franz cells with Albumin-fluorescein isothiocyanate (FITC) absorbed on the nano-rods. Fluorescence and confocal studies on the skin samples showed FITC penetration through the skin along the channels formed by the nano-rods. Bradford protein assay on the collected fluid samples indicated a significant quantity of Albumin-FITC in the first 12 h. Low antibody titres were observed with immunisation on Balb/c mice with ovalbumin (OVA) antigen coated on the nano-rod chips. Nonetheless, due to the reduced dimensions of the nano-rods, our device offers the additional advantage of excluding the simultaneous entrance of microbial pathogens. Taken together, these results showed that ZnO nano-rods hold the potential for a safe, non-invasive, and painless intradermal drug delivery.
ISSN: 2079-4991
DOI: 10.3390/nano7060147
Rights: © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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