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Title: Plasma vitamin D deficiency is associated with poor sleep quality and night-time eating at mid-pregnancy in Singapore
Authors: Cheng, Tuck Seng
Loy, See Ling
Cheung, Yin Bun
Cai, Shirong
Colega, Marjorelee T.
Godfrey, Keith M.
Chong, Yap-Seng
Tan, Kok Hian
Shek, Lynette Pei-Chi
Lee, Yung Seng
Lek, Ngee
Chan, Jerry Kok Yen
Chong, Mary Foong-Fong
Fabian, Yap
Keywords: Vitamin D
Behavioral Circadian Rhythms
Issue Date: 2017
Source: Cheng, T. S., Loy, S. L., Cheung, Y. B., Cai, S., Colega, M. T., Godfrey, K. M., . . . Yap, F. (2017). Plasma Vitamin D Deficiency Is Associated With Poor Sleep Quality and Night-Time Eating at Mid-Pregnancy in Singapore. Nutrients, 9(4), 340-. doi:10.3390/nu9040340
Series/Report no.: Nutrients
Abstract: Plasma 25-hydroxyvitamin D (25OHD) deficiency, poor sleep quality, and night-time eating, have been independently associated with adverse pregnancy outcomes, but their inter-relationships are yet to be evaluated. We aimed to investigate the associations between maternal plasma 25OHD status and sleep quality and circadian eating patterns during pregnancy. Data on pregnant women (n = 890) from a prospective cohort (Growing Up in Singapore Towards healthy Outcomes) were analyzed. Plasma 25OHD concentration was measured, while the Pittsburgh sleep quality index (PSQI) and 24-h dietary recall were administered to women at 26–28 weeks’ gestation. Plasma 25OHD status was defined as sufficient (>75 nmol/L), insufficient (50–75 nmol/L), or deficient (<50 nmol/L). Poor sleep quality was defined by a total global PSQI score >5. Predominantly day-time (pDT) and predominantly night-time (pNT) were defined according to consumption of greater proportion of calories (i.e., >50%) from 07:00–18:59 and from 19:00–06:59, respectively. After adjustment for confounders, women with plasma 25OHD deficiency had higher odds of poor sleep quality (odds ratio (OR) 3.49; 95% confidence interval (CI) 1.84–6.63) and pNT eating (OR: 1.85; 95% CI 1.00–3.41) than those who were 25OHD sufficient. Our findings show the association of maternal plasma 25OHD deficiency with poor sleep quality and pNT eating at mid-pregnancy.
ISSN: 2072-6643
DOI: 10.3390/nu9040340
Rights: © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
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