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dc.contributor.authorGao, Yuen
dc.contributor.authorChan, Chon U.en
dc.contributor.authorGu, Qiushien
dc.contributor.authorLin, Xudongen
dc.contributor.authorZhang, Wencongen
dc.contributor.authorYeo, David Chen Loongen
dc.contributor.authorAlsema, Astrid Marliesen
dc.contributor.authorArora, Manishen
dc.contributor.authorChong, Mark Seow Khoonen
dc.contributor.authorShi, Pengen
dc.contributor.authorOhl, Claus-Dieteren
dc.contributor.authorXu, Chenjieen
dc.identifier.citationGao, Y., Chan, C. U., Gu, Q., Lin, X., Zhang, W., Yeo, D. C. L., Alsema, A. M., et al. (2016). Controlled nanoparticle release from stable magnetic microbubble oscillations. NPG Asia Materials, 8(4), e260-. doi:10.1038/am.2016.37en
dc.description.abstractMagnetic microbubbles (MMBs) are microbubbles (MBs) coated with magnetic nanoparticles (NPs). MMBs not only maintain the acoustic properties of MBs, but also serve as an important contrast agent for magnetic resonance imaging. Such dual-modality functionality makes MMBs particularly useful for a wide range of biomedical applications, such as localized drug/gene delivery. This article reports the ability of MMBs to release their particle cargo on demand under stable oscillation. When stimulated by ultrasound at resonant frequencies, MMBs of 450 nm to 200 μm oscillate in volume and surface modes. Above an oscillation threshold, NPs are released from the MMB shell and can travel hundreds of micrometers from the surface of the bubble. The migration of NPs from MMBs can be described with a force balance model. With this technology, we deliver doxorubicin-containing poly(lactic-co-glycolic acid) particles across a physiological barrier both in vitro and in vivo, with a 18-fold and 5-fold increase in NP delivery to the heart tissue of zebrafish and tumor tissue of mouse, respectively. The penetration of released NPs in tissues is also improved. The ability to remotely control the release of NPs from MMBs suggests opportunities for targeted drug delivery through/into tissues that are not easily diffused through or penetrated.en
dc.format.extent10 p.en
dc.relation.ispartofseriesNPG Asia Materialsen
dc.rights© 2016 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectDRNTU::Engineering::Chemical engineeringen
dc.subjectAcoustic Propertiesen
dc.titleControlled nanoparticle release from stable magnetic microbubble oscillationsen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen
dc.contributor.researchNTU-Northwestern Institute for Nanomedicineen
dc.description.versionPublished versionen
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