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Title: Controlled nanoparticle release from stable magnetic microbubble oscillations
Authors: Gao, Yu
Chan, Chon U.
Gu, Qiushi
Lin, Xudong
Zhang, Wencong
Yeo, David Chen Loong
Alsema, Astrid Marlies
Arora, Manish
Chong, Mark Seow Khoon
Shi, Peng
Ohl, Claus-Dieter
Xu, Chenjie
Keywords: Histology
DRNTU::Engineering::Chemical engineering
Acoustic Properties
Issue Date: 2016
Source: Gao, Y., Chan, C. U., Gu, Q., Lin, X., Zhang, W., Yeo, D. C. L., Alsema, A. M., et al. (2016). Controlled nanoparticle release from stable magnetic microbubble oscillations. NPG Asia Materials, 8(4), e260-. doi:10.1038/am.2016.37
Series/Report no.: NPG Asia Materials
Abstract: Magnetic microbubbles (MMBs) are microbubbles (MBs) coated with magnetic nanoparticles (NPs). MMBs not only maintain the acoustic properties of MBs, but also serve as an important contrast agent for magnetic resonance imaging. Such dual-modality functionality makes MMBs particularly useful for a wide range of biomedical applications, such as localized drug/gene delivery. This article reports the ability of MMBs to release their particle cargo on demand under stable oscillation. When stimulated by ultrasound at resonant frequencies, MMBs of 450 nm to 200 μm oscillate in volume and surface modes. Above an oscillation threshold, NPs are released from the MMB shell and can travel hundreds of micrometers from the surface of the bubble. The migration of NPs from MMBs can be described with a force balance model. With this technology, we deliver doxorubicin-containing poly(lactic-co-glycolic acid) particles across a physiological barrier both in vitro and in vivo, with a 18-fold and 5-fold increase in NP delivery to the heart tissue of zebrafish and tumor tissue of mouse, respectively. The penetration of released NPs in tissues is also improved. The ability to remotely control the release of NPs from MMBs suggests opportunities for targeted drug delivery through/into tissues that are not easily diffused through or penetrated.
DOI: 10.1038/am.2016.37
Rights: © 2016 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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