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dc.contributor.authorGupta, Praveshen
dc.contributor.authorLai, Si Minen
dc.contributor.authorSheng, Jianpengen
dc.contributor.authorTetlak, Piotren
dc.contributor.authorBalachander, Akhilaen
dc.contributor.authorClaser, Carlaen
dc.contributor.authorRenia, Laurenten
dc.contributor.authorKarjalainen, Klausen
dc.contributor.authorRuedl, Christianeen
dc.identifier.citationGupta, P., Lai, S. M., Sheng, J., Tetlak, P., Balachander, A., Claser, C., . . . Ruedl, C. (2016). Tissue-resident CD169 + macrophages form a crucial front line against plasmodium infection. Cell Reports, 16(6), 1749-1761. doi:10.1016/j.celrep.2016.07.010en
dc.description.abstractTissue macrophages exhibit diverse functions, ranging from the maintenance of tissue homeostasis, including clearance of senescent erythrocytes and cell debris, to modulation of inflammation and immunity. Their contribution to the control of blood-stage malaria remains unclear. Here, we show that in the absence of tissue-resident CD169+ macrophages, Plasmodium berghei ANKA (PbA) infection results in significantly increased parasite sequestration, leading to vascular occlusion and leakage and augmented tissue deposition of the malarial pigment hemozoin. This leads to widespread tissue damage culminating in multiple organ inflammation. Thus, the capacity of CD169+ macrophages to contain the parasite burden and its sequestration into different tissues and to limit infection-induced inflammation is crucial to mitigating Plasmodium infection and pathogenesis.en
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en
dc.format.extent20 p.en
dc.relation.ispartofseriesCell Reportsen
dc.rights© 2016 The Author(s). This is an open access article under the CC BY-NC-ND license (
dc.subjectPlasmodium Berghei Infectionen
dc.subjectDRNTU::Science::Biological sciencesen
dc.titleTissue-resident CD169 + macrophages form a crucial front line against plasmodium infectionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.versionPublished versionen
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