Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88773
Title: Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy
Authors: Zhen, Xu
Zhang, Jianjian
Huang, Jiaguo
Xie, Chen
Miao, Qingqing
Pu, Kanyi
Keywords: Activatable Macrotheranostic Probe
β-Galactosidase
Issue Date: 2018
Source: Zhen, X., Zhang, J., Huang, J., Xie, C., Miao, Q., & Pu, K. (2018). Macrotheranostic Probe with Disease-activated Near-infrared Fluorescence, Photoacoustic and Photothermal Signals for Imaging-guided Therapy. Angewandte Chemie International Edition, in press.
Series/Report no.: Angewandte Chemie International Edition
Abstract: Theranostics provides opportunities for precision cancer therapy. However, theranostic systems that simultaneously turn on their diagnostic signal and pharmacological action only in respond to targeted biomarker have been less exploited. We herein report the synthesis of a smart macrotheranostic probe that specifically turns on near‐infrared fluorescence, photoacoustic and photothermal signals in the presence of cancer‐overexpressed enzyme for imaging‐guided cancer therapy. Supervisor to the small‐molecule counterpart probe, the macrotheranostic probe has an ideal biodistribution and renal clearance, permitting passive targeting of tumor, in‐situ enzymatic activation of multimodal signals, and effective photothermal therapy. Our study thus provides a macromolecular approach towards activatable multimodal phototheranostics.
URI: https://hdl.handle.net/10356/88773
http://hdl.handle.net/10220/44726
ISSN: 1433-7851
DOI: 10.1002/anie.201803321
Rights: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Angewandte Chemie International Edition, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [https://doi.org/10.1002/anie.201803321].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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