Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88791
Title: Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47
Authors: Wang, Feng
Fang, Mingliang
Hinton, David E.
Chernick, Melissa
Jia, Shenglan
Zhang, Yingdan
Xie, Lingtian
Dong, Wenjing
Dong, Wu
Keywords: Polybrominated Diphenyl Ether
Coiling
Issue Date: 2018
Source: Wang, F., Fang, M., Hinton, D. E., Chernick, M., Jia, S., Zhang, Y., et al. (2018). Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere, 198, 342-350.
Series/Report no.: Chemosphere
Abstract: Polybrominated diphenyl ethers (PBDEs) are a group of brominated flame retardants that are ubiquitously detected in the environment and associated with adverse health outcomes. 6-OH-BDE-47 is a metabolite of the flame retardant, 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47), and there is increasing concern regarding its developmental neurotoxicity and endocrine disrupting properties. In this study, we report that early life exposure in zebrafish (Danio rerio) embryos to 6-OH-BDE-47 (50 and 100 nM) resulted in higher coiling frequency and significantly increased apoptotic cells in the brain. These effects were partially rescued by overexpression of thyroid hormone receptor β (THRβ) mRNA. Moreover, exposure to 100 nM 6-OH-BDE-47 significantly reduced the number of hypothalamic 5-hydroxytryptamine (5-HT, serotonin)-immunoreactive (5-HT-ir) neurons and the mRNA expression of tryptophan hydroxylase 2 (TPH2). These results indicate that 6-OH-BDE-47 affected thyroid hormone regulation through THRβ and negatively impacted the nervous system, in turn, affecting coiling behavior. Correlations of these endpoints suggest that coiling frequency could be used as an indicator of neurotoxicity in embryos.
URI: https://hdl.handle.net/10356/88791
http://hdl.handle.net/10220/44882
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2018.01.081
Rights: © 2018 Elsevier Ltd.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:CEE Journal Articles

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