Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/88799
Title: Surface enhanced Raman spectroscopy for malaria diagnosis and intradermal measurements
Authors: Yuen, Clement
Liu, Quan
Chen, Keren
Ju, Jian
Xiong, Aoli
Preiser, Peter
Keywords: Ramen
DRNTU::Science::Biological sciences
Surface Enhanced Raman Scattering (SERS)
DRNTU::Engineering::Bioengineering
Issue Date: 2018
Source: Liu, Q., Yuen, C., Chen, K., Ju, J., Xiong, A., & Preiser, P. (2018). Surface enhanced Raman spectroscopy for malaria diagnosis and intradermal measurements. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 10509, 1050902-. doi:10.1117/12.2294539
Series/Report no.: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Abstract: The biomarkers of many diseases such as malaria can be found in intradermal measurements. We will present two surface enhanced Raman spectroscopy (SERS) based methods for the detection of malaria biomarkers in blood, which are comparable to or outperform the standard clinical method. To eliminate the need of drawing blood, we will also report a stainless-steel microneedle based probe for direct intradermal SERS measurements. Moreover, we developed a deformable agarose needle to reduce the risk of sharp injury and cross contamination due to needle reuse. Tests in skin phantoms for glucose measurements demonstrated accuracy comparable to those traditional methods requiring blood drawing.
URI: https://hdl.handle.net/10356/88799
http://hdl.handle.net/10220/45935
DOI: 10.1117/12.2294539
Rights: © 2018 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Progress in Biomedical Optics and Imaging - Proceedings of SPIE and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers (SPIE). The published version is available at: [http://dx.doi.org/10.1117/12.2294539]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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